AUTHOR=Kozlova Irina , Sah Saroj , Keable Ryan , Leshchyns’ka Iryna , Janitz Michael , Sytnyk Vladimir 

TITLE=Cell Adhesion Molecules and Protein Synthesis Regulation in Neurons

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=13

YEAR=2020

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2020.592126

DOI=10.3389/fnmol.2020.592126

ISSN=1662-5099

ABSTRACT=<p>Cell adhesion molecules (CAMs) mediate interactions of neurons with the extracellular environment by forming adhesive bonds with CAMs on adjacent membranes or <italic>via</italic> binding to proteins of the extracellular matrix. Binding of CAMs to their extracellular ligands results in the activation of intracellular signaling cascades, leading to changes in neuronal structure and the molecular composition and function of neuronal contacts. Ultimately, many of these changes depend on the synthesis of new proteins. In this review, we summarize the evidence showing that CAMs regulate protein synthesis by modulating the activity of transcription factors, gene expression, protein translation, and the structure and distribution of organelles involved in protein synthesis and transport.</p>