AUTHOR=González de San Román Estíbaliz , Manuel Iván , Ledent Catherine , Chun Jerold , Rodríguez de Fonseca Fernando , Estivill-Torrús Guillermo , Santín Luis Javier , Rodríguez Puertas Rafael TITLE=CB1 and LPA1 Receptors Relationship in the Mouse Central Nervous System JOURNAL=Frontiers in Molecular Neuroscience VOLUME=12 YEAR=2019 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2019.00223 DOI=10.3389/fnmol.2019.00223 ISSN=1662-5099 ABSTRACT=
Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, differentiation, oxidative stress, inflammation and apoptosis. Endocannabinoids (eCBs) and lysophosphatidic acid (LPA) are examples of this type of molecule and are involved in neuroprotection. The present study analyzes a possible relationship of the main receptor subtypes for both neurolipid systems that are present in the central nervous system, the CB1 and LPA1 receptors, by using brain slices from CB1 KO mice and LPA1-null mice. Receptor-mediated G protein activation and glycerophospholipid regulation of potential precursors of their endogenous neurotransmitters were measured by two different