AUTHOR=Wang Xizhi , Botchway Benson O. A. , Zhang Yong , Yuan Jiaying , Liu Xuehong 

TITLE=Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=12

YEAR=2019

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2019.00081

DOI=10.3389/fnmol.2019.00081

ISSN=1662-5099

ABSTRACT=<p>Spinal cord injury (SCI) can result in an irreversible disability due to loss of sensorimotor function below the lesion. Presently, clinical treatments for SCI mainly include surgery, drugs and postoperative rehabilitation. The prospective roles of bioscaffolds and exosomes in several neurological diseases have been reported. Bioscaffolds can reconnect lesion gaps as well as transport cells and bioactive factors, which in turn can improve axonal and functional regeneration. Herein, we explicate the respective roles of bioscaffolds and exosomes in SCI, and elucidate on the usage of combinational therapy involving bioscaffolds and extracellular vesicles (EVs) in improving SCI.</p>