AUTHOR=Tao Guangxu , Li Zhenmeiyu , Wen Yan , Song Xiaolei , Wei Song , Du Heng , Yang Zhengang , Xu Zhejun , You Yan 

TITLE=Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=12

YEAR=2019

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2019.00075

DOI=10.3389/fnmol.2019.00075

ISSN=1662-5099

ABSTRACT=<p>Cortical interneurons are derived from the subpallium and reach the developing cortex through long tangential migration. Mature cortical interneurons are characterized by remarkable morphological, molecular, and functional diversity. The calcium-binding protein parvalbumin (PV) and neuropeptide somatostatin (SST) identify most medial ganglionic eminence (MGE)-derived cortical interneurons. Previously, we demonstrated that <italic>Sp9</italic> plays a curial transcriptional role in regulating MGE-derived cortical interneuron development. Here, we show that SP8 protein is weekly expressed in the MGE mantle zone of wild type mice but upregulated in <italic>Sp9</italic> null mutants. PV<sup>+</sup> cortical interneurons were severely lost in <italic>Sp8/Sp9</italic> double conditional knockouts due to defects in tangential migration compared with <italic>Sp9</italic> single mutants, suggesting that <italic>Sp8/9</italic> coordinately regulate PV<sup>+</sup> cortical interneuron development. We provide evidence that <italic>Sp8/Sp9</italic> activity is required for normal MGE-derived cortical interneuron migration, at least in part, through regulating the expression of <italic>EphA3</italic>, <italic>Ppp2r2c</italic>, and <italic>Rasgef1b</italic>.</p>