AUTHOR=Paparelli Alessandra , Iwata Keiko , Wakuda Tomoyasu , Iyegbe Conrad , Murray Robin M. , Takei Nori TITLE=Perinatal Asphyxia in Rat Alters Expression of Novel Schizophrenia Risk Genes JOURNAL=Frontiers in Molecular Neuroscience VOLUME=Volume 10 - 2017 YEAR=2017 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2017.00341 DOI=10.3389/fnmol.2017.00341 ISSN=1662-5099 ABSTRACT=
Epidemiological studies suggest that obstetric complications, particularly those related to hypoxia during labor and delivery, are a risk factor for development of schizophrenia. The impact of perinatal asphyxia on postnatal life has been studied in a rodent model of global hypoxia, which is accompanied by cesarean section birth. This asphyxia model shows several behavioral, pharmacological, neurochemical, and neuroanatomical abnormalities in adulthood that have relevance to schizophrenia. Further, it is suggested that schizophrenia has a strong genetic component, and indeed novel candidate genes were recently identified by a genome-wide association study. Here, we examined alteration in the novel schizophrenia risk genes,