AUTHOR=Bartholome Odile , Van den Ackerveken Priscilla , Sánchez Gil Judit , de la Brassinne Bonardeaux Orianne , Leprince Pierre , Franzen Rachelle , Rogister Bernard TITLE=Puzzling Out Synaptic Vesicle 2 Family Members Functions JOURNAL=Frontiers in Molecular Neuroscience VOLUME=10 YEAR=2017 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2017.00148 DOI=10.3389/fnmol.2017.00148 ISSN=1662-5099 ABSTRACT=

Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer’s or Parkinson’s disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders.