AUTHOR=Del Turco Domenico , Paul Mandy H. , Schlaudraff Jessica , Hick Meike , Endres Kristina , Müller Ulrike C. , Deller Thomas TITLE=Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus JOURNAL=Frontiers in Molecular Neuroscience VOLUME=9 YEAR=2016 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2016.00134 DOI=10.3389/fnmol.2016.00134 ISSN=1662-5099 ABSTRACT=
The physiological role of amyloid precursor protein (APP) has been extensively investigated in the rodent hippocampus. Evidence suggests that APP plays a role in synaptic plasticity, dendritic and spine morphogenesis, neuroprotection and—at the behavioral level—hippocampus-dependent forms of learning and memory. Intriguingly, however, studies focusing on the role of APP in synaptic plasticity have reported diverging results and considerable differences in effect size between the dentate gyrus (DG) and area CA1 of the mouse hippocampus. We speculated that regional differences in APP expression could underlie these discrepancies and studied the expression of APP in both regions using immunostaining,