AUTHOR=Yang Weili , Tu Zhuchi , Sun Qiang , Li Xiao-Jiang 

TITLE=CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=9

YEAR=2016

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2016.00030

DOI=10.3389/fnmol.2016.00030

ISSN=1662-5099

ABSTRACT=<p>CRISPR/Cas9 is now used widely to genetically modify the genomes of various species. The ability of CRISPR/Cas9 to delete DNA sequences and correct DNA mutations opens up a new avenue to treat genetic diseases that are caused by DNA mutations. In this review, we describe the advantages of using CRISPR/Cas9 to engineer genomic DNAs in animal embryos, as well as in specific regions or cell types in the brain. We also discuss how to apply CRISPR/Cas9 to establish animal models of neurodegenerative diseases, such as Parkinson’s and Huntington’s disease (HD), and to treat these disorders that are caused by genetic mutations.</p>