AUTHOR=Fernandez-Moya Sandra M. , Bauer Karl E. , Kiebler Michael A. TITLE=Meet the players: local translation at the synapse JOURNAL=Frontiers in Molecular Neuroscience VOLUME=7 YEAR=2014 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2014.00084 DOI=10.3389/fnmol.2014.00084 ISSN=1662-5099 ABSTRACT=

It is widely believed that activity-dependent synaptic plasticity is the basis for learning and memory. Both processes are dependent on new protein synthesis at the synapse. Here, we describe a mechanism how dendritic mRNAs are transported and subsequently translated at activated synapses. Furthermore, we present the players involved in the regulation of local dendritic translation upon neuronal stimulation and their molecular interplay that maintain local proteome homeostasis. Any dysregulation causes several types of neurological disorders including muscular atrophies, cancers, neuropathies, neurodegenerative, and cognitive disorders.