AUTHOR=Atkin Graham , Paulson Henry 

TITLE=Ubiquitin pathways in neurodegenerative disease

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=7

YEAR=2014

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2014.00063

DOI=10.3389/fnmol.2014.00063

ISSN=1662-5099

ABSTRACT=<p>Control of proper protein synthesis, function, and turnover is essential for the health of all cells. In neurons these demands take on the additional importance of supporting and regulating the highly dynamic connections between neurons that are necessary for cognitive function, learning, and memory. Regulating multiple unique synaptic protein environments within a single neuron while maintaining cell health requires the highly regulated processes of ubiquitination and degradation of ubiquitinated proteins through the proteasome. In this review, we examine the effects of dysregulated ubiquitination and protein clearance on the handling of disease-associated proteins and neuronal health in the most common neurodegenerative diseases.</p>