AUTHOR=Popugaeva Elena , Bezprozvanny Ilya TITLE=Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease JOURNAL=Frontiers in Molecular Neuroscience VOLUME=6 YEAR=2013 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2013.00029 DOI=10.3389/fnmol.2013.00029 ISSN=1662-5099 ABSTRACT=

Alzheimer disease (AD) is a major threat of twenty-first century that is responsible for the majority of dementia in the elderly. Development of effective AD-preventing therapies are the top priority tasks for neuroscience research. Amyloid hypothesis of AD is a dominant idea in the field, but so far all amyloid-targeting therapies have failed in clinical trials. In addition to amyloid accumulation, there are consistent reports of abnormal calcium signaling in AD neurons. AD neurons exhibit enhanced intracellular calcium (Ca²⁺) liberation from the endoplasmic reticulum (ER) and reduced store-operated Ca²⁺ entry (SOC). These changes occur primarily as a result of ER Ca²⁺ overload. We argue that normalization of intracellular Ca²⁺ homeostasis could be a strategy for development of effective disease-modifying therapies. The current review summarizes recent data about changes in ER Ca²⁺ signaling in AD. Ca²⁺ channels that are discussed in the current review include: inositol trisphosphate receptors, ryanodine receptors, presenilins as ER Ca²⁺ leak channels, and neuronal SOC channels. We discuss how function of these channels is altered in AD and how important are resulting Ca²⁺ signaling changes for AD pathogenesis.