AUTHOR=Kerrigan Talitha L., Whitcomb Daniel , Regan Philip , Cho Kwangwook 

TITLE=The role of neuronal calcium sensors in balancing synaptic plasticity and synaptic dysfunction

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=5

YEAR=2012

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2012.00057

DOI=10.3389/fnmol.2012.00057

ISSN=1662-5099

ABSTRACT=<p>Neuronal calcium sensors (NCS) readily bind calcium and undergo conformational changes enabling them to interact and regulate specific target molecules. These interactions lead to dynamic alterations in protein trafficking that significantly impact upon synaptic function. Emerging evidence suggests that NCS and alterations in Ca<sup>2+</sup> mobilization modulate glutamate receptor trafficking, subsequently determining the expression of different forms of synaptic plasticity. In this review, we aim to discuss the functional relevance of NCS in protein trafficking and their emerging role in synaptic plasticity. Their significance within the concept of “translational neuroscience” will also be highlighted, by assessing their potential as key molecules in neurodegeneration.</p>