AUTHOR=Bradley Clarrisa A., Peineau Stephane , Taghibiglou Changiz , Nicolas Celine S., Whitcomb Daniel J., Bortolotto Zuner A., Kaang Bong-Kiun , Cho Kwangwook , Wang Yu-Tian , Collingridge Graham L.

TITLE=A pivotal role of GSK-3 in synaptic plasticity

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=5

YEAR=2012

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2012.00013

DOI=10.3389/fnmol.2012.00013

ISSN=1662-5099

ABSTRACT=<p>Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.</p>