AUTHOR=Kim Woo-Yang , Snider William D. TITLE=Functions of GSK-3 Signaling in Development of the Nervous System JOURNAL=Frontiers in Molecular Neuroscience VOLUME=4 YEAR=2011 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2011.00044 DOI=10.3389/fnmol.2011.00044 ISSN=1662-5099 ABSTRACT=

Glycogen synthase kinase-3 (GSK-3) is central to multiple intracellular pathways including those activated by Wnt/β-catenin, Sonic Hedgehog, Notch, growth factor/RTK, and G protein-coupled receptor signals. All of these signals importantly contribute to neural development. Early attention on GSK-3 signaling in neural development centered on the regulation of neuronal polarity using in vitro paradigms. However, recent creation of appropriate genetic models has demonstrated the importance of GSK-3 to multiple aspects of neural development including neural progenitor self-renewal, neurogenesis, neuronal migration, neural differentiation, and synaptic development.