AUTHOR=Hanin Geula , Soreq Hermona TITLE=Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes JOURNAL=Frontiers in Molecular Neuroscience VOLUME=4 YEAR=2011 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2011.00028 DOI=10.3389/fnmol.2011.00028 ISSN=1662-5099 ABSTRACT=
MicroRNAs (miRs) have emerged as important gene silencers affecting many target mRNAs. Here, we report the identification of 244 miRs that target the 3′-untranslated regions of different cholinesterase transcripts: 116 for butyrylcholinesterase (BChE), 47 for the synaptic acetylcholinesterase (AChE-S) splice variant, and 81 for the normally rare splice variant AChE-R. Of these, 11 and 6 miRs target both AChE-S and AChE-R, and AChE-R and BChE transcripts, respectively. BChE and AChE-S showed no overlapping miRs, attesting to their distinct modes of miR regulation. Generally, miRs can suppress a number of targets; thereby controlling an entire battery of functions. To evaluate the importance of the cholinesterase-targeted miRs in other specific biological processes we searched for their other experimentally validated target transcripts and analyzed the