AUTHOR=García-Ayllón Maria-Salud , Small David H , Avila Jesus , Saez-Valero Javier 

TITLE=Revisiting the Role of Acetylcholinesterase in Alzheimer’s Disease: Cross-Talk with P-tau and β-Amyloid

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=4

YEAR=2011

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2011.00022

DOI=10.3389/fnmol.2011.00022

ISSN=1662-5099

ABSTRACT=<p>A common feature in the Alzheimer’s disease (AD) brain is the presence of acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and neurofibrillary tangles (NFT). Although our understanding of the relationship between AChE and the pathological features of AD is incomplete, increasing evidence suggests that both β-amyloid protein (Aβ) and abnormally hyperphosphorylated tau (P-tau) can influence AChE expression. We also review recent findings which suggest the possible role of AChE in the development of a vicious cycle of Aβ and P-tau dysregulation and discuss the limited and temporary effect of therapeutic intervention with AChE inhibitors.</p>