AUTHOR=Cheang Iokfai , Zhu Qingqing , Liao Shengen , Li Xinli 

TITLE=Current Understanding of piRNA in Cardiovascular Diseases

JOURNAL=Frontiers in Molecular Medicine

VOLUME=1

YEAR=2022

URL=https://www.frontiersin.org/journals/molecular-medicine/articles/10.3389/fmmed.2021.791931

DOI=10.3389/fmmed.2021.791931

ISSN=2674-0095

ABSTRACT=<p>The relationship regarding non-coding genomes and cardiovascular disease (CVD) has been explored in the past decade. As one of the leading causes of death, there remains a lack of sensitive and specific genomic biomarkers in the diagnosis and prognosis of CVD. Piwi-interacting RNA (piRNA) is a group of small non-coding RNA (ncRNA) which associated with Piwi proteins. There is an emerging strong body of evidence in support of a role for ncRNAs, including piRNAs, in pathogenesis and prognosis of CVD. This article reviews the current evidence for piRNA-regulated mechanisms in CVD, which could lead to the development of new therapeutic strategies for prevention and treatment.</p>