Frontiers in Molecular Biosciences

Original Research

Published on 20 Feb 2025

Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites

in Molecular Diagnostics and Therapeutics

Ivana Kurelac
Manuela Sollazzo
Monica De Luise
Francesca Nanetti
Laura Lanteri
Luigi D’Angelo
Beatrice Cavina
Simona Corrà
Stefano Miglietta
Sara Milioni

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1537407

603 views

Review

Published on 20 Feb 2025

Two sides of the same coin: heat shock proteins as biomarkers and therapeutic targets for some complex diseases

in Protein Biochemistry for Basic and Applied Sciences

Xolani Henry Makhoba

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1491227

1,021 views

Editorial

Published on 19 Feb 2025

Editorial: Experimental and computational methods in the development of diagnostics and therapeutics for colon cancer

in Molecular Diagnostics and Therapeutics

Muhammad Suleman
Shahid Ali
Farooq Rashid
Faez Iqbal Khan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1568721

532 views

Original Research

Published on 17 Feb 2025

Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis

in Molecular Diagnostics and Therapeutics

Chunjiang Tan
Juan Wang
Xiangrong Ye
Kaidirina Kasimu
Ye Li
Feng Luo
Hui Yi
Yifeng Luo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1507163

1,167 views

Original Research

Published on 14 Feb 2025

A CRISPR-Cas-based recombinase polymerase amplification assay for ultra-sensitive detection of active Trypanosoma brucei evansi infections

in Molecular Diagnostics and Therapeutics

Andrés Álvarez-Rodríguez
Zeng Li
Bo-Kyung Jin
Benoit Stijlemans
Peter Geldhof
Stefan Magez

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1512970

1,052 views

Original Research

Published on 14 Feb 2025

An unfolded protein response (UPR)-signature regulated by the NFKB–miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer

in Molecular Diagnostics and Therapeutics

Jian Zhang
Xiaosong Fan
Yu Chen
Yichao Han
Weixing Yu
Shaolin Zhang
Bicheng Yang
Junlong Zhang
Yanling Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1542650

679 views

Original Research

Published on 14 Feb 2025

Metabolite profiling, antimalarial potentials of Schleichera oleosa using LC-MS and GC-MS: in vitro, molecular docking and molecular dynamics

in Biological Modeling and Simulation

Peetha Vanaja
N. S. Hari Narayana Moorthy
Vivek Singh Rajpoot
Harshawardhan Rao
Rohit Kumar Goswami
Paranthaman Subash
Sulekha Khute
Kareti Srinivasa Rao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1543939

878 views

Original Research

Published on 13 Feb 2025

Blood pressure improvement after resection of non-functioning adrenal adenomas: influencing factors and serum metabolic features

in Metabolomics

Jianlei Zhang
Peiqiang Wu
Yule Chen
Min Wang
Wenbin Song

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1524121

502 views

Editorial

Published on 13 Feb 2025

Editorial: Omics in endocrinology: from biomarker discovery to targeting therapeutic strategies

in Metabolomics

Michele Costanzo
Shereen M. Aleidi
Anas Abdel Rahman

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1567250

564 views

Original Research

Published on 13 Feb 2025

Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels—a single-centre retrospective study

in Protein Biochemistry for Basic and Applied Sciences

Anna-Elisabeth Minder
Francesca Granata
Franziska van Breemen
Xiaoye Schneider-Yin
Elisabeth I. Minder
Lanja Saleh
Jasmin Barman-Aksözen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1509803

714 views

Original Research

Published on 13 Feb 2025

Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma

in Molecular Diagnostics and Therapeutics

Xiaoxuan Tang
Shanxing Dang
Jie Qiu
Ruilan Zhou
Jing Ling
Limei Zhang
Xiaopeng Peng
Qingyun Li
Jin Liu
Wei Liao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1530253

1,121 views

Original Research

Published on 11 Feb 2025

IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury

in Molecular Diagnostics and Therapeutics

Hongshuang Su
Xiaoxi Lin
Ayinuer Paredong
Congcong Yao
Yan Zhang
Mengke Geng
Yuqian Guan
Lichao Gong
Feng Jiang
Qi Lv

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1538526

1,209 views

Original Research

Published on 11 Feb 2025

Simulations of pH and thermal effects on SARS-CoV-2 spike glycoprotein

in Biological Modeling and Simulation

Ziyuan Niu
Georgios Kementzidis
Miriam Rafailovich
Marcia Simon
Evangelos Papadopoulos
Bertal H. Aktas
Yuefan Deng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1545041

569 views

Original Research

Published on 11 Feb 2025

Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer

in Molecular Diagnostics and Therapeutics

Angelica Nogueira Rodrigues
Andreza Karine de Barros Almeida Souto
Diocésio Alves Pinto de Andrade
Larissa Müller Gomes
Sandra Satie Koide
Renata de Godoy e Silva
Bruno Batista de Souza
Juliana Doblas Massaro
Andréia Cristina de Melo
Andrea Morais Borges

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1524594

772 views

Review

Accepted on 10 Feb 2025

FOXOs and their roles in acute and chronic neurological disorders

in Molecular Diagnostics and Therapeutics

Yasin Asadi
Rozenn K Moundounga
Anand Chakroborty
Augustina Pokokiri
Hongmin Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1538472

115 views

Editorial

Published on 10 Feb 2025

Editorial: The emerging role of protein methylation/demethylation modification in disease and homeostasis

in Cellular Biochemistry

Yan-Jun Liu
Jian-Fei Lu
Xin Peng
Guan-Jun Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1565598

501 views