ORIGINAL RESEARCH article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1566363
This article is part of the Research Topic Integrative Multi-Omics Approaches for Predicting Immunotherapy Efficacy in Solid Tumors View all articles
TNFAIP8L3 regulation of TGF-β signaling pathway affects the proportion of macrophages during tumor antigen presentation and affects the prognosis of ovarian cancer
Provisionally accepted
- 1 Department of Gynecology and Obstetrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong Province, China
- 2 Department of General Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- 3 School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, Scotland, United Kingdom
- 4 Harbin Medical University, Harbin, China
- 5 Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, China
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Ovarian cancer is a serious disease that is a danger to a woman's life and health and is currently being extensively studied worldwide. TNFAIP8L3, as a member of the tumor necrosis family, plays a highly significant role in tumor immune regulation; however, its role in ovarian cancer has not been fully studied and reported.This study used data from 381 cases of ovarian cancer (OVCA) from TCGA-OV to analyze the clinical phenotype and immune phenotype of TNFAIP8L3. Pearson correlation coefficient and PPI protein network analyses were used to identify potential biological functions and the genes co-expressed with TNFAIP8L3. The Gene Set Enrichment Analysis (GSEA) is method was used to evaluate the relevant regulatory pathways of TNFAIP8L3. The Gene Set Variation Analysis was performed OV [Dannie Li]:to evaluate the proportions of 24 immune cells in OVCA. Finally, a nomogram and multivariate COX regression analysis were performed to prove the independent prognostic value of TNFAIP8L3 in OVCA.A total of 181 genes were co-expressed with TNFAIP8L3, including 163 positively correlated and 18 negatively correlated genes. The co-expressed genes associated with TNFAIP8L3 were significantly enriched in biological processes such as cell activation involved in immune response and leukocyte activation involved in immune response.Pathway analysis of TNFAIP8L3 further revealed the association of TNFAIP8L3 with the TGF-β signaling pathway and antigen processing and presentation pathways, especially with macrophages and neutrophils in the antigen presentation process.Moreover, the expression of TNFAIP8L3 was significantly high in OVCA and other solid tumors and can function as an independent risk factor for the prognosis of OVCA, with important research value for the prognosis of patients with OVCA.Those findings indicate that TNFAIP8L3 is correlated with antigen processing and presentation pathways in macrophages and neutrophils and affects prognosis and immune infiltration in OVCA.
Keywords: TNFAIP8L3 (TIPE3), TGF-β signaling pathway, ovarian cancer, Antigen Presentation, TCGA database
Received: 24 Jan 2025; Accepted: 13 Mar 2025.
Copyright: © 2025 Yue, Zheng, Ye, Li and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanhong Zhou, Department of Gynecology and Obstetrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong Province, China
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