Editorial: The Emerging Role of Protein Methylation/Demethylation Modification in Disease and Homeostasis

Yanjun Liu ^1,2 Jianfei Lu ^2* Xin Peng ^3* Guan-Jun Yang ^1,2*

• ¹ School of Marine Sciences, Ningbo University, Ningbo, China
• ² Ningbo University, Ningbo, China
• ³ Ningbo Traditional Chinese Medicine Hospital, Ningbo, Zhejiang Province, China

The significance of protein methylation and demethylation extends beyond basic cellular functions; they are critical in numerous biological processes, including development, differentiation, and epigenetic regulation. For instance, histone methylation is a well-studied modification that orchestrates chromatin structure and gene expression, influencing cellular identity and function. Additionally, the methylation of non-histone proteins, such as transcription factors and signaling molecules, further underscores the complexity and importance of these modifications in regulating cellular activities. These modifications are not only fundamental to basic cellular functions but also have profound implications in more complex biological phenomena and diseases. Understanding the intricate mechanisms underlying protein methylation and demethylation is crucial for unraveling their roles in normal physiology and disease pathology. As research in this area progresses, it holds the promise of revealing potential therapeutic opportunities that could transform our approach to treating various diseases. proteins they target, and their involvement in chemoresistance, along with their inhibitors and 104 mechanisms of action. The review also addresses current challenges and future directions for PMT 105 inhibitors in combating cancer chemoresistance.