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REVIEW article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 |
doi: 10.3389/fmolb.2025.1541230
The role of potential oxidative biomarkers in the Prognosis of Intracerebral Hemorrhage and the exploration antioxidants as possible Preventive and Treatment options
Provisionally accepted
Jiayong Yao 1*
xiaohong dai 1* xueping yv 1* lei zheng 2* jia zheng 1* binglin kuang 3* wei teng 1* weiwei yu 1* mignyue li 1* hongtao cao 1* wei zou 1,2*- 1 First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
- 2 Clinical Key Laboratory of Integrated Traditional Chinese and Western Medicine of Heilongjiang University of Chinese Medicine, Harbin, Jilin Province, China
- 3 Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
Intracerebral hemorrhage (ICH) is a non traumatic hemorrhage that occurs in a certain part of the brain. It usually leads to brain cell damage. According to a large number of experimental research, oxidative stress is an important pathophysiological processes of cerebral hemorrhage. In this paper, we aim to determine how changes in oxidative stress biomarkers indicate the damage degree of cerebral hemorrhage, and to explore and summarize potential treatments or interventions. We found that patients with cerebral hemorrhage are characterized by increased levels of oxidative stress markers, such as total malondialdehyde (MDA), F2 isoprostaglandin, hydroxynonenal, myeloperoxidase and protein hydroxyl. Therefore, the changes of oxidative stress caused by ICH on these markers can be used to evaluate and diagnose ICH, predict its prognosis, and guide preventive treatment to turn to antioxidant based treatment as a new treatment alternative.
Keywords: Oxidative Stress, intracerebral hemorrhage, Oxidative Stress biomarkers, antioxidant therapy, Stroke
Received: 09 Dec 2024; Accepted: 15 Jan 2025.
Copyright: © 2025 Yao, dai, yv, zheng, zheng, kuang, teng, yu, li, cao and zou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiayong Yao, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
xiaohong dai, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
xueping yv, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
lei zheng, Clinical Key Laboratory of Integrated Traditional Chinese and Western Medicine of Heilongjiang University of Chinese Medicine, Harbin, Jilin Province, China
jia zheng, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
binglin kuang, Heilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang Province, China
wei teng, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
weiwei yu, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
mignyue li, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
hongtao cao, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
wei zou, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
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