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REVIEW article
Front. Mol. Biosci.
Sec. RNA Networks and Biology
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1537861
This article is part of the Research Topic RNA Processing in Chronic Diseases View all 7 articles
RNA Modifications and Their Role in Gene Expression
Provisionally accepted- 1 Department of Biochemsitry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Bogor, Indonesia
- 2 Department of Biochemsitry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
- 3 Department of Medical Chemsitry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
- 4 Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Post-transcriptional RNA modifications have recently emerged as critical regulators of gene expression programs. Understanding normal tissue development and disease susceptibility requires knowledge of the various cellular mechanisms which control gene expression in multicellular organisms. Research into how different RNA modifications such as in N6-methyladenosine (m 6 A), inosine (I), 5methylcytosine (m 5 C), pseudouridine (Ψ), 5-hydroxymethylcytosine (hm 5 C), N1-methyladenosine (m 1 A), N6,2'-O-dimethyladenosine (m 6 Am), 2'-O-methylation (Nm), N7-methylguanosine (m 7 G) etc. affect the expression of genes could be valuable. This review highlights the current understanding of RNA modification, methods used to study RNA modification, types of RNA modification, and molecular mechanisms underlying RNA modification. The role of RNA modification in modulating gene expression in both physiological and diseased states is discussed. The potential applications of RNA modification in therapeutic development are elucidated.
Keywords: RNA, RNA modification, Epitranscriptomics, Gene Expression, RNA Editing, Therapeutic developement
Received: 01 Dec 2024; Accepted: 02 Apr 2025.
Copyright: © 2025 Artika, Arianti, Demény and Kristóf. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
I Made Artika, Department of Biochemsitry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Bogor, Indonesia
Endre Kristóf, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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