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ORIGINAL RESEARCH article
Front. Mol. Biosci.
Sec. Nanobiotechnology
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1530469
Carbon dots derived from Zingiber officinale Rosc (ginger) with hemostatic effects
Provisionally accepted- Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
Ginger, as a traditional Chinese medicine (TCM), can be used in clinical practice to treat various diseases. The product of ginger processed at high temperatures is called carbonized ginger (CG), which has a hemostatic effect that ginger originally did not have. Through research, it has been found that CG contains a component with a size range of 1-10 nm, called carbon dots (CDs). The CG-CDs were characterized by transmission electron microscopy (TEM), high-resolution TEM (HR-TEM), ultraviolet-visible (UV-Vis), Ffourier transform infrared (FT-IR), and fluorescence (FL) spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and thin layer chromatography (TLC). In addition, pharmacological experiments have shown that CG-CDs mainly activate exogenous coagulation pathways and cocoagulation pathways, increase platelet count, increase platelet activating factor TXB2, decrease 6-keto-PGF1α, increase PAI-1, and decrease t-PA, thereby affecting the fibrinolytic system and other pathways to exert hemostatic effects. To our knowledge, this is the first study on the hemostatic effect of CG-CD, which provides a research basis for future research on the hemostatic effect of CG and offers new strategies for exploring the hemostatic effect of charcoal drugs.
Keywords: Hemostatic effects, carbon dots, Zingiber officinale rosc, Carbonized ginger, Traditional Chinese Medicine
Received: 19 Nov 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Hu, Yu, Bi, Zhang, Wang, Meng and Kuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wang Meng, Heilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang Province, China
Hai-Xue Kuang, Heilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang Province, China
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