feng jian Bin ^1,2 Longfei Chen ^1,2 Yan Wang ^1,2 Hua Ge ^2,3* Wei Chen ^2,3*

• ¹ medical postgraduate, Zunyi, China
• ² First People’s Hospital of Zunyi, Zunyi, Guizhou Province, China
• ³ chief physician, zunyi, China

Colorectal cancer (CRC) is the third most prevalent malignant tumour in the world, accounting for about 10% of all cancer cases and the second leading cause of cancer-related deaths. In addition, in recent years, with the improvement of people's living standards and gradual changes in dietary habits, as well as factors such as familial inheritance, the incidence and mortality rates of colorectal cancer have been on the rise globally. Prompt diagnosis and effective treatment are crucial in significantly improving the survival rates of colorectal cancer patients. Various factors, including gender, environmental factors, lifestyle choices, and genetic predispositions, contribute to the onset of colorectal cancer.Both genetic and epigenetic alterations have been identified as potential causes of CRC. And recent research highlights that circular RNAs (circRNAs) are a new class of non-coding RNAs that play a key role in CRC development. circRNAs are predominantly found in cancer cells and tissues, solid tumours, peripheral blood, exosomes and body fluids (e.g. serum, plasma and saliva), Due to their resistance to degradation and their presence in body fluids, circRNAs are non-invasive, perfect candidates for liquid biopsy and therefore have high diagnostic potential. More than a dozen upregulated circRNAs are actively involved in the development and progression of CRC, and their silencing produces opposite effects in vitro and in vivo. Therefore, these oncogenic circRNAs may serve as potential therapeutic targets, and targeting the unique back-splice junctions of oncogenic circRNAs for degradation by siRNAs may have antitumour properties. In contrast, downregulated circRNAs negatively regulate CRC growth and metastasis. Due to their high stability and long half-life, tumour suppressor circRNAs may have significant anti-tumour effects when expressed in CRC cells or tissues. circRNAs represent the cutting edge of tumour biology and therapy, and no less than hundreds of aberrantly expressed circRNAs have been detected in CRC tissues, many of which have been shown to regulate CRC cell proliferation, migration, invasion and apoptosis. many of which have been shown to regulate CRC cell proliferation, migration, invasion and apoptosis.