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REVIEW article

Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1510975
This article is part of the Research Topic Mechanistic Studies on Protein Acylation View all articles

Recent advances of lysine lactylation in prokaryotes and eukaryotes

Provisionally accepted
Wenjuan Zhao Wenjuan Zhao 1,2Jiayi Xin Jiayi Xin 2,3*Xin Yu Xin Yu 2*Zhifang Li Zhifang Li 3*Nan Li Nan Li 2*
  • 1 School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China
  • 2 Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, CAS Key Laboratory of Quantitative Engineering Biology, shenzhen, China
  • 3 School of Life Sciences, Henan University, Kaifeng, Henan Province, China

The final, formatted version of the article will be published soon.

    Lysine lactylation is a newly discovered protein post-translational modification that plays regulatory roles in cell metabolism, growth, reprogramming, and tumor progression. It utilizes lactate as the modification precursor, which is an end product of glycolysis while functioning as a signaling molecule in cells. Unlike previous reviews focused primarily on eukaryotes, this review aims to provide a comprehensive summary of recent knowledge about lysine lactylation in prokaryotes and eukaryotes. The current identification and enrichment strategies for lysine lactylation are introduced, and the known readers, writers, and erasers of this modification are summarized. In addition, the physiological and pathological implications of lysine lactylation are reviewed for different organisms, especially in prokaryotic cells. Finally, we end with a discussion of the limitations of the studies so far and propose future directions for lysine lactylation investigations.

    Keywords: Lysine lactylation, post-translational modification, Lactate, cell metabolism, tumorigenesis

    Received: 14 Oct 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Zhao, Xin, Yu, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiayi Xin, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, CAS Key Laboratory of Quantitative Engineering Biology, shenzhen, China
    Xin Yu, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, CAS Key Laboratory of Quantitative Engineering Biology, shenzhen, China
    Zhifang Li, School of Life Sciences, Henan University, Kaifeng, 475004, Henan Province, China
    Nan Li, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, CAS Key Laboratory of Quantitative Engineering Biology, shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.