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ORIGINAL RESEARCH article

Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1502509
This article is part of the Research Topic Cancer Biomarkers: Molecular Insights into Diagnosis, Prognosis, and Risk Prediction View all 5 articles

Identification of genetic associations between acute myocardial infarction and non-small cell lung cancer

Provisionally accepted
Hao Zheng Hao Zheng 1Jie Wang Jie Wang 2Yijia Zheng Yijia Zheng 1Xiaofan Hong Xiaofan Hong 1Luxi Wang Luxi Wang 3*
  • 1 First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • 2 Department of Psychiatry, Wenzhou Seventh Peoples Hospital, Wenzhou, Zhejiang Province, China
  • 3 Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    A growing body of evidence suggests a potential connection between myocardial infarction (MI) and lung cancer (LC). However, the underlying pathogenesis and molecular mechanisms remain unclear. This research aims to identify common genes and pathways between MI and LC through bioinformatics analysis. Two public datasets (GSE166780 and GSE8569) were analyzed to identify differentially expressed genes (DEGs). Common DEGs were enriched using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Hub genes were identified and their diagnostic performance was evaluated. Gene co-expression networks, as well as regulatory networks involving miRNA-hub genes and TF-hub genes, were also constructed. Finally, candidate drugs were predicted. Among the datasets, 34 common trend DEGs were identified. Enrichment analysis linked these DEGs to key biological processes, cellular components, and molecular functions. Eight hub genes (CEBPA, TGFBR2, EZH2, JUNB, JUN, FOS, PLAU, COL1A1) were identified, demonstrating promising diagnostic accuracy. Key transcription factors associated with these hub genes include SP1, ESR1, CREB1, ETS1, NFKB1, and RELA, while key miRNAs include hsa-mir- 101-3p, hsa-mir-124-3p, hsa-mir-29c-3p, hsa-mir-93-5p, and hsa-mir-155-5p. Additionally, potential therapeutic drugs were identified, with zoledronic acid anhydrous showing potential value in reducing the cooccurrence of the two diseases. Overall, we identified eight hub genes and their co-regulatory pathways between the two diseases, providing new insights for further studies on molecular mechanisms.

    Keywords: Non-small cell lung cancer (NSCLC), Acute myocardial infarction (AMI), Differentially Expressed Genes (DEGs), Hub genes, Bioinformatics analysis

    Received: 27 Sep 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Zheng, Wang, Zheng, Hong and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Luxi Wang, Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.