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REVIEW article

Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1490275

Autophagy-Lysosomal Pathway Impairment and Cathepsin Dysregulation in Alzheimer's Disease

Provisionally accepted
Alquiandra Stefani F. Mançano Alquiandra Stefani F. Mançano Juliana G. Pina Juliana G. Pina Bruna R. Froes Bruna R. Froes Juliana M. Sciani Juliana M. Sciani *
  • Sao Francisco University, Braganca Paulista, Brazil

The final, formatted version of the article will be published soon.

    Alzheimer's disease (AD) is characterized by neuronal loss, attributed to amyloid-beta (Aβ) aggregation and accumulation. The autophagy-lysosomal pathway, including cathepsins B and D, is crucial for protein degradation and clearance, but it is impaired in some diseases. This review summarizes current knowledge on the dysregulation of this pathway in AD. Accumulating evidence suggests that Aβ overload impairs autophagy-lysosomal function and cathepsin activity, exacerbating Aβ accumulation and neurodegeneration. However, the precise mechanisms underlying these interactions remain elusive. Despite these challenges, targeting the lysosomal pathway emerges as a promising therapeutic strategy, and a comprehensive understanding of the autophagy-lysosomal system is essential to develop effective interventions for AD.

    Keywords: Alzheimer's disease1, Autophagy2, Lysosome3, β-amyloid4, cathepsin B5, cathepsin D6

    Received: 02 Sep 2024; Accepted: 15 Oct 2024.

    Copyright: © 2024 Mançano, Pina, Froes and Sciani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Juliana M. Sciani, Sao Francisco University, Braganca Paulista, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.