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REVIEW article

Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1472492

Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes

Provisionally accepted
Qingyuan Yu Qingyuan Yu *Yanan Xiao Yanan Xiao Mengqi Guan Mengqi Guan JIANAN YU JIANAN YU XianShuai Zhang XianShuai Zhang Mingze Han Mingze Han Zhen-hua LI Zhen-hua LI *
  • Changchun University of Chinese Medicine, Changchun, China

The final, formatted version of the article will be published soon.

    Ferroptosis, an iron-ion-dependent process of lipid peroxidation, damages the plasma membrane, leading to non-programmed cell death. Osteoarthritis (OA), a prevalent chronic degenerative joint disease among middle-aged and older adults, is characterized by chondrocyte damage or loss.Emerging evidence indicates that chondrocyte ferroptosis plays a role in OA development.However, most research has concentrated on ferroptosis regulation involving typical iron ions, potentially neglecting the significance of elevated copper ions in both serum and joint fluid of patients with OA. This review aims to fill this gap by systematically examining the interplay between copper metabolism, oxidative stress, ferroptosis, and copper-associated cell death in OA.It will provide a comprehensive overview of copper ions' role in regulating ferroptosis and their dual role in OA. This approach seeks to offer new insights for further research, prevention, and treatment of OA.

    Keywords: ferroptosis, copper homeostasis, Oxidative Stress, Osteoarthritis, Chondrocytes, dual regulation, Cuproptosis Ferroptosis, cuproptosis

    Received: 29 Jul 2024; Accepted: 29 Aug 2024.

    Copyright: © 2024 Yu, Xiao, Guan, YU, Zhang, Han and LI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qingyuan Yu, Changchun University of Chinese Medicine, Changchun, China
    Zhen-hua LI, Changchun University of Chinese Medicine, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.