AUTHOR=Zulueta Diaz Yenisleidy de las Mercedes , Arnspang Eva C. 

TITLE=Super-resolution microscopy to study membrane nanodomains and transport mechanisms in the plasma membrane

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2024.1455153

DOI=10.3389/fmolb.2024.1455153

ISSN=2296-889X

ABSTRACT=<p>Biological membranes are complex, heterogeneous, and dynamic systems that play roles in the compartmentalization and protection of cells from the environment. It is still a challenge to elucidate kinetics and real-time transport routes for molecules through biological membranes in live cells. Currently, by developing and employing super-resolution microscopy; increasing evidence indicates channels and transporter nano-organization and dynamics within membranes play an important role in these regulatory mechanisms. Here we review recent advances and discuss the major advantages and disadvantages of using super-resolution microscopy to investigate protein organization and transport within plasma membranes.</p>