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REVIEW article

Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1454456

Pathogenic Role of PFKFB3 in Endothelial Inflammatory Diseases

Provisionally accepted
Ling Zhou Ling Zhou Juan Li Juan Li Juanjuan Wang Juanjuan Wang Xuping Niu Xuping Niu Junqin Li Junqin Li Kaiming Zhang Kaiming Zhang *
  • Taiyuan Central Hospital, Taiyuan, China

The final, formatted version of the article will be published soon.

    Abstract：The differentiation of vascular endothelial cells and the formation of new blood vessels are inseparable from the energy supply and regulation of metabolism.The budding of blood vessels is a starting point of glycolysis pathway in angiogenesis.Phosphofructokinase-2 /fructose 2,6-biophosphatase 3 (PFKFB3), a key rate-limiting enzyme in glycolysis, exhibits strong kinase activity. Inhibition of PFKFB3 can reduce the rate of glycolysis, thereby inhibiting the budding of blood vessels, resulting in inhibition of pathological angiogenesis. In this review, the role of PFKFB3 in the angiogenesis of inflammatory diseases was summarized, and the endothelial inflammatory diseases associated with PFKFB3 were reviewed.

    Keywords: PFKFB3, Endothelial Cells, Glycolysis, Inflammatory, 3PO

    Received: 25 Jun 2024; Accepted: 30 Aug 2024.

    Copyright: © 2024 Zhou, Li, Wang, Niu, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kaiming Zhang, Taiyuan Central Hospital, Taiyuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.