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ORIGINAL RESEARCH article

Front. Mol. Biosci.
Sec. Metabolomics
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1431329

Causal Relationship between Plasma Metabolites and Carpal Tunnel Syndrome Risk: evidence from a Mendelian randomization study

Provisionally accepted
Wenbao Wu Wenbao Wu *Daofeng Fan Daofeng Fan Rui Qiu Rui Qiu Binfu Que Binfu Que Qingqing Lian Qingqing Lian Yangui Chen Yangui Chen Rui Qiu Rui Qiu
  • Longyan First Hospital Affiliated to Fujian Medical University, Longyan, China

The final, formatted version of the article will be published soon.

    Carpal tunnel syndrome (CTS) is a common symptom of nerve compression and a leading cause of pain and hand dysfunction. However, the underlying biological mechanisms are not fully understood. The aim of this study was to reveal the causal effect of circulating metabolites on susceptibility to CTS.Variance Weighted, MR-Egger, Weighted Median, Simple Mode, and Weighted Model, to examine the association between 1400 metabolites and the risk of developing CTS. We obtained Single-nucleotide polymorphisms (SNPs) associated with 1400 metabolites from the Canadian Longitudinal Study on Aging (CLSA) cohort. CTS data was derived from the FinnGen consortium, which included 11,208 cases and 195,047 controls of European ancestry.The results of the two-sample MR study indicated an association between 77 metabolites (metabolite ratios) and CTS. After false discovery rate (FDR) correction, a strong causal association between glucuronate levels (odd ratio (OR) [95% CI]: 0.98 [0.97-0.99], p FDR= 0.002), adenosine 5'-monophosphate (AMP) to phosphate ratio (OR[95% CI]:0.58 [0.45-0.74], p FDR= 0.009), cysteinylglycine disulfide levels(OR [95% CI] : 0.85 [0.78-0.92], p FDR= 0.047) and CTS was finally identified.In summary, the results of this study suggest that the identified glucuronate, the ratio of AMP to phosphate, and cysteinylglycine disulfide levels can be considered as metabolic biomarkers for CTS screening and prevention in future clinical practice, as well as candidate molecules for future mechanism exploration and drug target selection.

    Keywords: Carpal Tunnel Syndrome, Mendelian randomization, Metabolites, Glucuronate, Cysteinylglycine disulfide, Adenosine 5'-monophosphate to phosphate ratio

    Received: 03 Jun 2024; Accepted: 13 Sep 2024.

    Copyright: © 2024 Wu, Fan, Qiu, Que, Lian, Chen and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wenbao Wu, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, China

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