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REVIEW article

Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1428794
This article is part of the Research Topic LncRNA and Their Role on Epigenome in Cancer View all articles

The epigenetic and epitranscriptomic role of lncRNA in carcinogenesis

Provisionally accepted
Chunfei Dai Chunfei Dai 1,2Haoyue Qianjiang Haoyue Qianjiang 1,2Ruishuang Fu Ruishuang Fu 1Huimin Yang Huimin Yang 1Aiqin Shi Aiqin Shi 3Huacheng Luo Huacheng Luo 1*
  • 1 Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), The Chinese Academy of Sciences, Hangzhou, China
  • 2 College of Pharmacy, Zhejiang University of Technology, Hangzhou, Jiangsu Province, China
  • 3 Xianghu Laboratory, Hangzhou, China

The final, formatted version of the article will be published soon.

    Long non-coding RNAs (lncRNAs) have emerged as the critical players in the regulation of gene expression by mediating epigenetic and epitranscriptomic modifications. Dysregulation of lncRNAs has been implicated in tumor initiation, progression, and metastasis. Recent studies indicate that lncRNAs modulate chromatin structure and gene transcription by recruiting various epigenetic regulators, including DNA-modifying enzymes or histone-modifying enzymes. Additionally, lncRNAs mediate chromatin remodeling and enhancer/promoter long-range chromatin interactions to control oncogene expression by recruiting chromatin organization associated proteins, thereby promoting carcinogenesis. Furthermore, lncRNAs aberrantly induce the oncogene expression through mediating epitranscriptomic modifications, including RNA methylation and RNA editing. Overall, we have summarized the regulatory mechanisms of lncRNAs in cancers to unravel the complex interplay between lncRNAs and epigenetic/epitranscriptomic regulators in carcinogenesis. This kind of work is meaningful to find new potential biomarkers and targets for cancer diagnosis and therapeutics. In conclusion, this review aims to provide a new perspective on epigenetic and epitranscriptomic roles of lncRNAs in carcinogenesis.

    Keywords: lncRNA, DNA modification, histone modification, chromatin organization, RNA modification, Epigenetic regulation, epitranscriptomic regulation, Carcinogenesis

    Received: 07 May 2024; Accepted: 02 Jul 2024.

    Copyright: © 2024 Dai, Qianjiang, Fu, Yang, Shi and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Huacheng Luo, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), The Chinese Academy of Sciences, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.