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REVIEW article
Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 11 - 2024 |
doi: 10.3389/fmolb.2024.1408287
The role of actin cytoskeleton CFL1 and ADF/cofilin superfamily in inflammatory response
Provisionally accepted- Taiyuan Central Hospital, Taiyuan, Shanxi Province, China
Actin remodeling proteins are important in immune diseases and regulate cell cytoskeletal responses. These responses play a pivotal role in maintaining the delicate balance of biological events, protecting against acute or chronic inflammation in a range of diseases. Cofilin (CFL) and actin depolymerization factor (ADF) are potent actin-binding proteins that cut and depolymerize actin filaments to generate actin cytoskeleton dynamics. Although the molecular mechanism by which actin induces actin cytoskeletal reconstitution has been studied for decades, the regulation of actin in the inflammatory process has only recently become apparent. In this paper, the functions of the actin cytoskeleton and ADF/cofilin superfamily members are briefly introduced, and then focus on the role of CFL1 in inflammatory response.
Keywords: Actin Cytoskeleton, Inflammation, CFL1, ADF/cofilin superfamily, cell migration
Received: 28 Mar 2024; Accepted: 04 Jul 2024.
Copyright: © 2024 Xing, Wang, Peng, Li, Niu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kaiming Zhang, Taiyuan Central Hospital, Taiyuan, 030027, Shanxi Province, China
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