Skip to main content

REVIEW article

Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1408287

The role of actin cytoskeleton CFL1 and ADF/cofilin superfamily in inflammatory response

Provisionally accepted
Jianxiao Xing Jianxiao Xing Ying Wang Ying Wang Aihong Peng Aihong Peng Junqin Li Junqin Li Xuping Niu Xuping Niu Kaiming Zhang Kaiming Zhang *
  • Taiyuan Central Hospital, Taiyuan, Shanxi Province, China

The final, formatted version of the article will be published soon.

    Actin remodeling proteins are important in immune diseases and regulate cell cytoskeletal responses. These responses play a pivotal role in maintaining the delicate balance of biological events, protecting against acute or chronic inflammation in a range of diseases. Cofilin (CFL) and actin depolymerization factor (ADF) are potent actin-binding proteins that cut and depolymerize actin filaments to generate actin cytoskeleton dynamics. Although the molecular mechanism by which actin induces actin cytoskeletal reconstitution has been studied for decades, the regulation of actin in the inflammatory process has only recently become apparent. In this paper, the functions of the actin cytoskeleton and ADF/cofilin superfamily members are briefly introduced, and then focus on the role of CFL1 in inflammatory response.

    Keywords: Actin Cytoskeleton, Inflammation, CFL1, ADF/cofilin superfamily, cell migration

    Received: 28 Mar 2024; Accepted: 04 Jul 2024.

    Copyright: © 2024 Xing, Wang, Peng, Li, Niu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kaiming Zhang, Taiyuan Central Hospital, Taiyuan, 030027, Shanxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.