Eudald Casals
Shunbo Li
Zhiyu Jia
Gregori Casals
Muling Zeng- 1School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China
- 2Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education and Key Disciplines Laboratory of Novel Micro-Nano Devices and System Technology, College of Optoelectronic Engineering, Chongqing University, Chongqing, China
- 3Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China
- 4Service of Biochemistry and Molecular Genetics, Hospital Clinic Universitari and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
- 5Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD), Madrid, Spain
- 6Department of Fundamental Care and Medical-Surgical Nursing, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
Editorial on the Research Topic
Advanced functional nanomaterials for diagnosis, bioimaging, drug delivery and dherapeutics
In the healthcare domain, nanomaterials play a pivotal role in simultaneous disease detection and treatment, addressing conditions such as cancer (Casals et al., 2017), neurological disorders (Liu et al., 2021), cardiovascular diseases (Smith and Edelman, 2023) and inflammatory processes (Casals et al., 2020), among others. The emergence of theranostic nanomedicines offers flexible platforms tailored for personalized treatments. In addition, owing to their inherent detectability by many biomedical imaging techniques, combined with the robust nanostructures developed in recent years providing shelter and/or stability to incorporated active molecules, nanomaterials are perfectly suited for combined diagnostics and therapy (Zeng et al., 2021) and some even exhibit intrinsic therapeutic actions (Prabhakar et al., 2021), such as phototherapy and anti-inflammatory treatments (Parra-Robert et al., 2019). However, the application of nanomaterials in health-related domains has not been without its challenges (Ghorbani et al., 2021). The inherent complexity of physiological processes necessitates high standards for the development and deployment of these advanced functional nanomaterials, demanding innovative solutions to ensure efficacy, safety, and compatibility within intricate biological systems.
A significant contribution to the scenario described above is the review article by Long et al. which addressed the rising concern of brain metastases (BrM) and associated challenges with current breakthrough therapies enabled by nanomaterials. The article first discussed how malignant tumor cells manipulate the brain microenvironment, transitioning it from anti-tumoral to pro-tumoral. It then compared the characteristics of the brain microenvironment in BrM with other sites or primary tumors. Subsequently, the article evaluated microenvironment-targeted therapies enabled by nanomaterials, showcasing promise in overcoming drug resistance and low blood-brain barrier permeability. The article suggested how these diverse therapies could lead to improved outcomes for patients with secondary brain tumors.
Continuing with novel therapies to interact with complex pathophysiological processes, the original research article by Xu et al. introduced a supramolecular strategy to extend the in vivo half-life and improve tumor targeting of therapeutic proteins. The study focused on the fusion of trichosanthin (TCS) with the self-assembling protein Sup35p prion domain (Sup35), resulting in the formation of uniform spherical TCS-Sup35 nanoparticles (TCS-Sup35 NP) with pH-responsive characteristics. TCS-Sup35 NP retained the bioactivity of TCS and exhibited a significantly longer in vivo half-life than native TCS. In a tumor-bearing mouse model, TCS-Sup35 NP showed improved tumor accumulation and antitumor activity without detectable systemic toxicity, presenting a promising solution for enhancing the pharmacological performance of therapeutic proteins with short circulation half-lives.
Furthermore, addressing unmet clinical needs poses challenges for the application of nanomaterials, including intricate synthesis processes of sophisticated nanoparticles and Research Topic with drug delivery nanocarriers, such as slow release in physiological conditions. The review article by Zhang et al. explored cutting-edge applications of DNA origami in antitumor drug delivery. DNA origami, a revolutionary self-assembly technique, creates precise nanostructures with lower biotoxicity, increased stability, and superior adaptability. The review discussed principles, design strategies, and the latest research achievements of DNA origami in anti-tumor drug delivery, emphasizing the potential to reduce side effects and enhance therapy success through precise, targeted, and multifunctional drug delivery systems. The article also explored the use of DNA tetrahedra in addressing drug delivery challenges in cancer therapy.
Importantly, nanomaterials involved in therapeutics or imaging must address biocompatibility and biosafety Research Topic within the human body. The original research article by Liu et al. focused on using Rhodobacter sphaeroides as a biological model to study the ecotoxicity of 1-alkyl-3-methylimidazolium bromide ([Cnmim]Br), an ionic liquid. The study correlated the inhibition of bacterial growth with the alkyl chain length and investigated morphological changes, including cell membrane perforation. The research utilized electrochromic absorption bands to demonstrate linear correlations with the alkyl chain length. Moreover, it observed effects on ATP synthesis and antioxidant enzyme activity. The findings proposed Rhodobacter sphaeroides as a valuable model for monitoring ecotoxicity and understanding the mechanisms of ionic liquid toxicity. Importantly, this study addressed both safety aspects and demonstrated improved specificity and sensitivity, vital for diagnostic applications.
In summary, this Research Topic invited global contributions from professionals in industry, academia, and research institutions, with the aim of accelerating advancements in advanced functional nanomaterials for more effective diagnosis, bioimaging, drug delivery, and therapeutic interventions. This collaborative effort has explored and contributed to framing recent advancements and challenges in the broad intersection of nanotechnology and healthcare.
Author contributions
EC: Writing–original draft, Writing–review and editing. SL: Writing–original draft. ZJ: Writing–review and editing. GC: Writing–review and editing. MZ: Writing–original draft, Writing–review and editing.
Funding
The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The author(s) declare financial support was received for the research, authorship, and/or publication of this article. MZ acknowledges support from the National Natural Science Foundation of China (22005221) and the Wuyi University (2018TP011 and 2020FKZX05). EC acknowledges support from the Wuyi University (2018TP010). GC acknowledges support from the Instituto de Salud Carlos III (PI19/00774 and BA22/00017), co-funded by the European Regional Development Fund, European Union, “A way to make Europe”.
Acknowledgments
The editors would like to thank all the authors and expert reviewers who have participated in the preparation and evaluation of manuscripts presented in this Research Topic.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
Casals, E., Gusta, M. F., Cobaleda-Siles, M., Garcia-Sanz, A., and Puntes, V. F. (2017). Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles. Cancer Nanotechnol. 8 (1), 7. doi:10.1186/s12645-017-0030-4
Casals, E., Zeng, M., Parra-Robert, M., Fernández-Varo, G., Morales-Ruiz, M., Jiménez, W., et al. (2020). Cerium oxide nanoparticles: cerium oxide nanoparticles: advances in biodistribution, toxicity, and preclinical exploration (small 20/2020). Small 16 (20), 2070111. doi:10.1002/smll.202070111
Ghorbani, M., Izadi, Z., Jafari, S., Casals, E., Rezaei, F., Aliabadi, A., et al. (2021). Preclinical studies conducted on nanozyme antioxidants: shortcomings and challenges based on US FDA regulations. Nanomedicine 16 (13), 1133–1151. doi:10.2217/nnm-2021-0030
Liu, Y., Wang, X., Li, X., Qiao, S., Huang, G., Hermann, D. M., et al. (2021). A Co-doped Fe(3)O(4) nanozyme shows enhanced reactive oxygen and nitrogen species scavenging activity and ameliorates the deleterious effects of ischemic stroke. ACS Appl. Mater Interfaces 13 (39), 46213–46224. doi:10.1021/acsami.1c06449
Parra-Robert, M., Casals, E., Massana, N., Zeng, M., Perramón, M., Fernández-Varo, G., et al. (2019). Beyond the scavenging of reactive oxygen species (ROS): direct effect of cerium oxide nanoparticles in reducing fatty acids content in an in vitro model of hepatocellular steatosis. Biomolecules 9 (9), 425. doi:10.3390/biom9090425
Prabhakar, N., Merisaari, J., Le Joncour, V., Peurla, M., Karaman, D. Ş., Casals, E., et al. (2021). Circumventing drug treatment? Intrinsic lethal effects of polyethyleneimine (PEI)-Functionalized nanoparticles on glioblastoma cells cultured in stem cell conditions. Cancers 13 (11), 2631. doi:10.3390/cancers13112631
Smith, B. R., and Edelman, E. R. (2023). Nanomedicines for cardiovascular disease. Nat. Cardiovasc. Res. 2 (4), 351–367. doi:10.1038/s44161-023-00232-y
Keywords: advanced functional and healthcare materials, drug delievery, bioimaging, diagnosis, nanomedicine
Citation: Casals E, Li S, Jia Z, Casals G and Zeng M (2024) Editorial: Advanced functional nanomaterials for diagnosis, bioimaging, drug delivery and therapeutics. Front. Mol. Biosci. 11:1399695. doi: 10.3389/fmolb.2024.1399695
Received: 12 March 2024; Accepted: 18 March 2024;
Published: 25 March 2024.
Edited and reviewed by:
Matteo Becatti, University of Firenze, ItalyCopyright © 2024 Casals, Li, Jia, Casals and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Muling Zeng, bXVsaW5nemVuZ0AxNjMuY29t; Eudald Casals, d3l1Y2hlbWVjbUAxMjYuY29t