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ORIGINAL RESEARCH article

Front. Mol. Biosci.
Sec. Metabolomics
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1356043

Lipidomics revealed alterations in glycerophospholipid metabolism in skin squamous cell carcinoma

Provisionally accepted
Li-Hong Mei Li-Hong Mei Hui-Hui Gan Hui-Hui Gan Hong-Feng Wang Hong-Feng Wang Guoxiong Xu Guoxiong Xu Xuan-Guang Ye Xuan-Guang Ye Gao YANG Gao YANG *
  • Jinshan Hospital, Fudan University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Background: Skin squamous cell carcinoma (SCC) is a prevalent malignancy, and dysregulated lipid metabolism has been implicated in its pathogenesis. However, detailed characterization of lipid alterations in SCC remains limited.We analyzed lipid metabolic variations in tissue samples from 34 SCC patients and adjacent healthy tissues (located more than 1 cm from the tumor margin) using liquid chromatography-mass spectrometry (LC-MS). Data visualization and discriminatory lipid profiles were identified using principal component analysis (PCA) and sparse partial least squares discriminant analysis (sPLS-DA). Key lipids involved in the SCC metabolism were identified and further validated using an external data set (from a previous study, which similarly explored lipid profiles in oral SCC using lipidomics approaches). Pathway enrichment analysis was conducted to elucidate the metabolic pathways associated with these key lipids.Results: Eight lipids were identified by comparing SCC and healthy tissues including PI(16:0/22:4),

    Keywords: Skin squamous cell carcinoma, lipidomics, glycerophospholipid metabolism, biomarkers, therapeutic targets

    Received: 26 Feb 2024; Accepted: 05 Jul 2024.

    Copyright: © 2024 Mei, Gan, Wang, Xu, Ye and YANG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Gao YANG, Jinshan Hospital, Fudan University, Shanghai, 200433, Shanghai Municipality, China

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