AUTHOR=Yang Xiaoyue , Liang Ying , Tong Sheng 

TITLE=Advancing cancer treatment: in vivo delivery of therapeutic small noncoding RNAs

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=10

YEAR=2024

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2023.1297413

DOI=10.3389/fmolb.2023.1297413

ISSN=2296-889X

ABSTRACT=<p>In recent years, small non-coding RNAs (ncRNAs) have emerged as a new player in the realm of cancer therapeutics. Their unique capacity to directly modulate genetic networks and target oncogenes positions them as valuable complements to existing small-molecule drugs. Concurrently, the advancement of small ncRNA-based therapeutics has rekindled the pursuit of efficacious <italic>in vivo</italic> delivery strategies. In this review, we provide an overview of the most current clinical and preclinical studies in the field of small ncRNA-based cancer therapeutics. Furthermore, we shed light on the pivotal challenges hindering the successful translation of these promising therapies into clinical practice, with a specific focus on delivery methods, aiming to stimulate innovative approaches to address this foundational aspect of cancer treatment.</p>