AUTHOR=Asarnow Daniel , Becker Vada A. , Bobe Daija , Dubbledam Charlie , Johnston Jake D. , Kopylov Mykhailo , Lavoie Nathalie R. , Li Qiuye , Mattingly Jacob M. , Mendez Joshua H. , Paraan Mohammadreza , Turner Jack , Upadhye Viraj , Walsh Richard M. , Gupta Meghna , Eng Edward T. 

TITLE=Recent advances in infectious disease research using cryo-electron tomography

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=10

YEAR=2024

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2023.1296941

DOI=10.3389/fmolb.2023.1296941

ISSN=2296-889X

ABSTRACT=<p>With the increasing spread of infectious diseases worldwide, there is an urgent need for novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) techniques, particularly electron tomography (cryo-ET), have revolutionized the field of infectious disease research by enabling multiscale observation of biological structures in a near-native state. This review highlights the recent advances in infectious disease research using cryo-ET and discusses the potential of this structural biology technique to help discover mechanisms of infection in native environments and guiding in the right direction for future drug discovery.</p>