AUTHOR=Yang Xin , Tang Zhe , Li Jing , Jiang Jizong , Liu Yue 

TITLE=Progress of non-small-cell lung cancer with ROS1 rearrangement

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2023.1238093

DOI=10.3389/fmolb.2023.1238093

ISSN=2296-889X

ABSTRACT=<p><italic>ROS1</italic> rearrangement is found in 0.9%–2.6% of people with non-small-cell lung cancers (NSCLCs). Tyrosine kinase inhibitors (TKIs) target <italic>ROS1</italic> and can block tumor growth and provide clinical benefits to patients. This review summarizes the current knowledge on <italic>ROS1</italic> rearrangements in NSCLCs, including the mechanisms of <italic>ROS1</italic> oncogenicity, epidemiology of <italic>ROS1</italic>-positive tumors, methods for detecting rearrangements, molecular characteristics, therapeutic agents, and mechanisms of drug resistance.</p>