AUTHOR=Burt Rajan A. , Alghusen Ibtihal M. , John Ephrame Sophiya , Villar Maria T. , Artigues Antonio , Slawson Chad 

TITLE=Mapping the O-GlcNAc Modified Proteome: Applications for Health and Disease

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2022.920727

DOI=10.3389/fmolb.2022.920727

ISSN=2296-889X

ABSTRACT=<p>O-GlcNAc is a pleotropic, enigmatic post-translational modification (PTM). This PTM modifies thousands of proteins differentially across tissue types and regulates diverse cellular signaling processes. O-GlcNAc is implicated in numerous diseases, and the advent of O-GlcNAc perturbation as a novel class of therapeutic underscores the importance of identifying and quantifying the O-GlcNAc modified proteome. Here, we review recent advances in mass spectrometry-based proteomics that will be critical in elucidating the role of this unique glycosylation system in health and disease.</p>