AUTHOR=Kuerschner Lars , Thiele Christoph TITLE=Tracing Lipid Metabolism by Alkyne Lipids and Mass Spectrometry: The State of the Art JOURNAL=Frontiers in Molecular Biosciences VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2022.880559 DOI=10.3389/fmolb.2022.880559 ISSN=2296-889X ABSTRACT=

Lipid tracing studies are a key method to gain a better understanding of the complex metabolic network lipids are involved in. In recent years, alkyne lipid tracers and mass spectrometry have been developed as powerful tools for such studies. This study aims to review the present standing of the underlying technique, highlight major findings the strategy allowed for, summarize its advantages, and discuss some limitations. In addition, an outlook on future developments is given.