AUTHOR=Cadet Frederic , Saavedra Emma , Syren Per-Olof , Gontero Brigitte TITLE=Editorial: Machine learning, epistasis, and protein engineering: From sequence-structure-function relationships to regulation of metabolic pathways JOURNAL=Frontiers in Molecular Biosciences VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2022.1098289 DOI=10.3389/fmolb.2022.1098289 ISSN=2296-889X