AUTHOR=Sarfraz Muhammad Hassan , Shahid Aqsa , Asghar Samra , Aslam Bilal , Ashfaq Usman Ali , Raza Hammad , Prieto Miguel A. , Simal-Gandara Jesus , Barba Francisco J. , Rajoka Muhammad Shahid Riaz , Khurshid Mohsin , Nashwan Abdulqadir J. TITLE=Personalized nutrition, microbiota, and metabolism: A triad for eudaimonia JOURNAL=Frontiers in Molecular Biosciences VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2022.1038830 DOI=10.3389/fmolb.2022.1038830 ISSN=2296-889X ABSTRACT=

During the previous few years, the relationship between the gut microbiota, metabolic disorders, and diet has come to light, especially due to the understanding of the mechanisms that particularly link the gut microbiota with obesity in animal models and clinical trials. Research has led to the understanding that the responses of individuals to dietary inputs vary remarkably therefore no single diet can be suggested to every individual. The variations are attributed to differences in the microbiome and host characteristics. In general, it is believed that the immanent nature of host-derived factors makes them difficult to modulate. However, diet can more easily shape the microbiome, potentially influencing human physiology through modulation of digestion, absorption, mucosal immune response, and the availability of bioactive compounds. Thus, diet could be useful to influence the physiology of the host, as well as to ameliorate various disorders. In the present study, we have described recent developments in understanding the disparities of gut microbiota populations between individuals and the primary role of diet-microbiota interactions in modulating human physiology. A deeper understanding of these relationships can be useful for proposing personalized nutrition strategies and nutrition-based therapeutic interventions to improve human health.