AUTHOR=Qasem Zena , Pavlin Matic , Ritacco Ida , Avivi Matan Y. , Meron Shelly , Hirsch Melanie , Shenberger Yulia , Gevorkyan-Airapetov Lada , Magistrato Alessandra , Ruthstein Sharon TITLE=Disrupting Cu trafficking as a potential therapy for cancer JOURNAL=Frontiers in Molecular Biosciences VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2022.1011294 DOI=10.3389/fmolb.2022.1011294 ISSN=2296-889X ABSTRACT=
Copper ions play a crucial role in various cellular biological processes. However, these copper ions can also lead to toxicity when their concentration is not controlled by a sophisticated copper-trafficking system. Copper dys-homeostasis has been linked to a variety of diseases, including neurodegeneration and cancer. Therefore, manipulating Cu-trafficking to trigger selective cancer cell death may be a viable strategy with therapeutic benefit. By exploiting combined