AUTHOR=Frenis Katie , Kalinovic Sanela , Ernst Benjamin P. , Kvandova Miroslava , Al Zuabi Ahmad , Kuntic Marin , Oelze Matthias , Stamm Paul , Bayo Jimenez Maria Teresa , Kij Agnieszka , Keppeler Karin , Klein Veronique , Strohm Lea , Ubbens Henning , Daub Steffen , Hahad Omar , Kröller-Schön Swenja , Schmeisser Michael J. , Chlopicki Stefan , Eckrich Jonas , Strieth Sebastian , Daiber Andreas , Steven Sebastian , Münzel Thomas TITLE=Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development JOURNAL=Frontiers in Molecular Biosciences VOLUME=8 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.814921 DOI=10.3389/fmolb.2021.814921 ISSN=2296-889X ABSTRACT=
Transportation noise is recognized as an important cardiovascular risk factor. Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. Here, we test for adaptation or tolerance mechanisms in mice in response to chronic noise exposure. C57BL/6J mice were exposed to aircraft noise for 0, 4, 7, 14 and 28d at a mean sound pressure level of 72 dB(A) and peak levels of 85 dB(A). Chronic aircraft noise exposure up to 28d caused persistent endothelial dysfunction and elevation of blood pressure. Likewise, reactive oxygen species (ROS) formation as determined by dihydroethidium (DHE) staining and HPLC-based measurement of superoxide formation in the aorta/heart/brain was time-dependently increased by noise. Oxidative burst in the whole blood showed a maximum at 4d or 7d of noise exposure. Increased superoxide formation in the brain was mirrored by a downregulation of neuronal nitric oxide synthase (