AUTHOR=Qin Wei , Li Yi-Heng , Tong Jing , Wu Jie , Zhao Dong , Li Hui-Jin , Xing Lu , He Chun-Xia , Zhou Xin , Li Peng-Quan , Meng Ge , Wu Shao-Ping , Cao Hui-Ling TITLE=Rational Design and Synthesis of 3-Morpholine Linked Aromatic-Imino-1H-Indoles as Novel Kv1.5 Channel Inhibitors Sharing Vasodilation Effects JOURNAL=Frontiers in Molecular Biosciences VOLUME=8 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.805594 DOI=10.3389/fmolb.2021.805594 ISSN=2296-889X ABSTRACT=
Atrial fibrillation (AF) is the most common clinical sustained arrhythmia; clinical therapeutic drugs have low atrial selectivity and might cause more severe ventricle arrhythmias while stopping AF. As an anti-AF drug target with high selectivity on the atrial muscle cells, the undetermined crystal structure of Kv1.5 potassium channel impeded further new drug development. Herein, with the simulated 3D structure of Kv1.5 as the drug target, a series of 3-morpholine linked aromatic amino substituted 1