AUTHOR=Azouzi Chaima , Jaafar Mariam , Dez Christophe , Abou Merhi Raghida , Lesne Annick , Henras Anthony K. , Gadal Olivier TITLE=Coupling Between Production of Ribosomal RNA and Maturation: Just at the Beginning JOURNAL=Frontiers in Molecular Biosciences VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.778778 DOI=10.3389/fmolb.2021.778778 ISSN=2296-889X ABSTRACT=
Ribosomal RNA (rRNA) production represents the most active transcription in the cell. Synthesis of the large rRNA precursors (35S/47S in yeast/human) is achieved by up to hundreds of RNA polymerase I (Pol I) enzymes simultaneously transcribing a single rRNA gene. In this review, we present recent advances in understanding the coupling between rRNA production and nascent rRNA folding. Mapping of the distribution of Pol I along ribosomal DNA at nucleotide resolution, using either