AUTHOR=Yan Qiang , Ni Chenming , Lin Yingying , Sun Xu , Shen Zhenhua , Zhang Minjie , Han Shuwen , Shi Jiemin , Mao Jing , Yang Zhe , Wang Weilin TITLE=ELK1 Enhances Pancreatic Cancer Progression Via LGMN and Correlates with Poor Prognosis JOURNAL=Frontiers in Molecular Biosciences VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.764900 DOI=10.3389/fmolb.2021.764900 ISSN=2296-889X ABSTRACT=
Pancreatic cancer is one of the most lethal cancers and its prognosis is extremely poor. Clarification of molecular mechanisms and identification of prognostic biomarkers are urgently needed. Though we previously found that LGMN was involved in pancreatic carcinoma progression, the upstream regulation of LGMN remains unknown. We used reliable software to search for the potential transcription factors that may be related with LGMN transcription, we found that ELK1 could be a new regulator of LGMN transcription that binded directly to the LGMN promoter. Moreover, knocking down of ELK1 reduced pancreatic cancer cells proliferation, invasion and survival, while LGMN restored the malignancy of pancreatic cancer