AUTHOR=Bartsch Benedikt , Goody Philip Roger , Hosen Mohammed Rabiul , Nehl Denise , Mohammadi Neda , Zietzer Andreas , Düsing Philip , Pfeifer Alexander , Nickenig Georg , Jansen Felix 

TITLE=NcRNAs in Vascular and Valvular Intercellular Communication

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.749681

DOI=10.3389/fmolb.2021.749681

ISSN=2296-889X

ABSTRACT=<p>Non-coding RNAs have been shown to be important biomarkers and mediators of many different disease entities, including cardiovascular (CV) diseases like atherosclerosis, aneurysms, and valvulopathies. Growing evidence suggests a central role of ncRNAs as regulators of different pathological pathways involved in endothelial dysfunction, cardiovascular inflammation, cell differentiation, and calcification. This review will discuss the role of protein-bound and extracellular vesicular-bound ncRNAs as biomarkers of vascular and valvular diseases, their role as intercellular communicators, and regulators of disease pathways and also highlights possible treatment strategies.</p>