AUTHOR=Shan Xiaoxiao , Zhang Caiyun , Mai Chutian , Hu Xuerui , Cheng Nuo , Chen Weidong , Peng Daiyin , Wang Lei , Ji Zhaojie , Xie Ying 

TITLE=The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.715461

DOI=10.3389/fmolb.2021.715461

ISSN=2296-889X

ABSTRACT=<p>Macrophage-derived exosomes have been implicated on the modulation of inflammatory processes. Recent studies have shown that macrophage-derived exosomes contribute to the progression of many diseases such as cancer, atherosclerosis, diabetes and heart failure. This review describes the biogenesis of macrophage-derived exosomes and their biological functions in different diseases. In addition, the challenges facing the use of macrophage-derived exosomes as delivery tools for drugs, genes, and proteins in clinical applications are described. The application of macrophage-derived exosomes in the diagnosis and treatment of diseases is also discussed.</p>