AUTHOR=Han Zhenyuan , Zhuang Xiaodong , Yang Biao , Jin Lihui , Hong Pengjie , Xue Junqing , Chen Shunjie , Tian Zhen 

TITLE=SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.714203

DOI=10.3389/fmolb.2021.714203

ISSN=2296-889X

ABSTRACT=<p><bold>Objectives:</bold> Gliomas remain one of serious public health problems worldwide which demand further and deeper investigation. The aim of this study was to explore the association between synapse defective protein 1 homolog 1 (<italic>SYDE1</italic>) and gliomas <italic>via</italic> public database analysis and <italic>in vitro</italic> validation to determine the potential diagnostic and prognostic values.</p><p><bold>Methods and Results:</bold> Compared with healthy brain tissues, there was a significant increase in <italic>SYDE1</italic> expression in glioma tissues. Additionally, <italic>SYDE1</italic> exhibited higher expression levels in glioma patients with unfavorable clinicopathological factors. <italic>In vitro</italic> knockdown of <italic>SYDE1</italic> in glioma cell lines A172 inhibited their migrative and invasive ability but not the proliferative ability. GO and KEGG pathway analysis of the top 100 genes coexpressed with <italic>SYDE1</italic> showed enrichments of tumor-associated terms. Further bioinformatic analysis revealed that the <italic>SNHG16/hsa-miR-520e/SYDE1</italic> axis might be involved in glioma development.</p><p><bold>Conclusions:</bold><italic>SYDE1</italic> is expressed at higher levels in gliomas than in healthy brains, and can promote metastasis and invasion but not proliferation of gliomas. Furthermore, <italic>SYDE1</italic> has values in the diagnosis and prognosis prediction of gliomas.</p>